Mouse Edem1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Edem1
Locus ID	192193
Kit Components	GA212706G1, Edem1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212706G2, Edem1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212706G3, Edem1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_138677
Synonyms	A130059K23Rik; EDEM; mKIAA0212
Summary	Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.[UniProtKB/Swiss-Prot Function]

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