Mouse Prpf8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prpf8
Locus ID	192159
Kit Components	GA212689G1, Prpf8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212689G2, Prpf8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212689G3, Prpf8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_138659
Synonyms	AU019467; D11Bwg0410e; DBF3/PRP8; Prp8; Sfprp8l
Summary	Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.[UniProtKB/Swiss-Prot Function]

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