Mouse Asic3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Asic3
Locus ID	171209
Kit Components	GA212643G1, Asic3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212643G2, Asic3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212643G3, Asic3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001310474, NM_183000
Synonyms	Accn3; AW742291; DRASIC; SLNAC1; TNAC1
Summary	Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.[UniProtKB/Swiss-Prot Function]

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