Mouse Tlr7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tlr7
Locus ID	170743
Kit Components	GA212589G1, Tlr7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212589G2, Tlr7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212589G3, Tlr7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001290755, NM_001290756, NM_001290757, NM_001290758, NM_133211
Summary	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[UniProtKB/Swiss-Prot Function]

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