Mouse Ttbk2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ttbk2
Locus ID	140810
Kit Components	GA212539G1, Ttbk2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212539G2, Ttbk2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212539G3, Ttbk2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001024856, NM_001024857, NM_080788
Synonyms	2610507N02Rik; AI326283; B930008N24Rik; mKIAA0847; Ttbk; Ttbk1; TTK
Summary	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.[UniProtKB/Swiss-Prot Function]

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