Mouse Sec63 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sec63
Locus ID	140740
Kit Components	GA212530G1, Sec63 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212530G2, Sec63 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212530G3, Sec63 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_153055, NM_001359283, NM_001359284, NM_001359285, NM_001359286
Synonyms	5730478J10Rik; AI649014; AW319215
Summary	Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (PubMed:21685914).[UniProtKB/Swiss-Prot Function]

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