Mouse Grk2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Grk2
Locus ID	110355
Kit Components	GA212313G1, Grk2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212313G2, Grk2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212313G3, Grk2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001290818, NM_130863
Synonyms	Adrbk-1; Bark-1; beta ARK; betaARK1; GRK2
Summary	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity.[UniProtKB/Swiss-Prot Function]

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