Mouse Card11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Card11
Locus ID	108723
Kit Components	GA212134G1, Card11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212134G2, Card11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212134G3, Card11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175362
Synonyms	0610008L17Rik; 2410011D02Rik; BIMP3; CARMA1
Summary	Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:12356734, PubMed:16356855). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway (By similarity).[UniProtKB/Swiss-Prot Function]

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