Mouse Eif4ebp3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Eif4ebp3
Locus ID	108112
Kit Components	GA212092G1, Eif4ebp3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212092G2, Eif4ebp3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212092G3, Eif4ebp3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_201256
Synonyms	4e-bp3
Summary	Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.[UniProtKB/Swiss-Prot Function]

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