Mouse Rnf216 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rnf216
Locus ID	108086
Kit Components	GA212085G1, Rnf216 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212085G2, Rnf216 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212085G3, Rnf216 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_080561, NM_207110, NM_001359851
Synonyms	2810055G22Rik; AI647468; AU019462; C86502; F830018F18Rik; TRIAD3; Ubce7ip1; UIP83
Summary	Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis.[UniProtKB/Swiss-Prot Function]

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