Mouse Mrpl41 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mrpl41
Locus ID	107733
Kit Components	GA212030G1, Mrpl41 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212030G2, Mrpl41 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212030G3, Mrpl41 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001031808
Synonyms	MRP-L27; Rpml27
Summary	Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.[UniProtKB/Swiss-Prot Function]

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