Mouse Brms1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Brms1
Locus ID	107392
Kit Components	GA211994G1, Brms1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211994G2, Brms1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211994G3, Brms1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_134155
Synonyms	AV003220; AW554636
Summary	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity).[UniProtKB/Swiss-Prot Function]

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