Mouse Fbxo38 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fbxo38
Locus ID	107035
Kit Components	GA211965G1, Fbxo38 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211965G2, Fbxo38 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211965G3, Fbxo38 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_134136, NM_001361088, NM_001361089, NM_001361090, NM_001361091
Synonyms	6030410I24Rik; AU044865; AW214031; Moka; SP329
Summary	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (PubMed:14729953, PubMed:16990251).[UniProtKB/Swiss-Prot Function]

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