Mouse Topors activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Topors
Locus ID	106021
Kit Components	GA211911G1, Topors gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211911G2, Topors gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211911G3, Topors gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_134097
Synonyms	AW105885; LUN; p53BP3/LUN; TP53BPL
Summary	Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.[UniProtKB/Swiss-Prot Function]

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