Mouse Mbnl2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mbnl2
Locus ID	105559
Kit Components	GA211881G1, Mbnl2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211881G2, Mbnl2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211881G3, Mbnl2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175341, NM_207515, NM_001360376, NM_001360377, NM_001360378, NM_001360379, NM_001360380
Synonyms	1110002M11Rik; AI047808; AI837313; AI849185; AL118326; MBLL; mKIAA4072; R75232
Summary	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3' UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity).[UniProtKB/Swiss-Prot Function]

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