Mouse Vipas39 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Vipas39
Locus ID	104799
Kit Components	GA211836G1, Vipas39 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211836G2, Vipas39 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211836G3, Vipas39 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001142580, NM_001142581, NM_134044
Synonyms	6720456H09Rik; 9330175H22Rik; AI413782; hSPE-39; SPE-39; Spe39; Vipar
Summary	Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin.[UniProtKB/Swiss-Prot Function]

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