Mouse Inca1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Inca1
Locus ID	103844
Kit Components	GA211768G1, Inca1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211768G2, Inca1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211768G3, Inca1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001252482, NM_001252483, NM_001252484, NM_001252485, NM_213729
Synonyms	AI842396
Summary	Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and proliferation and may play a role in cell cycle control (PubMed:21540187). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (PubMed:21750715).[UniProtKB/Swiss-Prot Function]

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