Mouse Maml1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Maml1
Locus ID	103806
Kit Components	GA211765G1, Maml1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211765G2, Maml1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211765G3, Maml1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_175334
Synonyms	AI644666; AW743257; D930008C07Rik; Mam-1; Mam1; mKIAA0200
Summary	Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.[UniProtKB/Swiss-Prot Function]

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