Mouse Smg6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Smg6
Locus ID	103677
Kit Components	GA211754G1, Smg6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211754G2, Smg6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211754G3, Smg6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001002764
Synonyms	AI317223; AU041178
Summary	Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).[UniProtKB/Swiss-Prot Function]

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