Mouse Rrp8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rrp8
Locus ID	101867
Kit Components	GA211674G1, Rrp8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211674G2, Rrp8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211674G3, Rrp8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_025897, NM_133951
Synonyms	1500003O22Rik; 2900001K19Rik; AW538116
Summary	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity).[UniProtKB/Swiss-Prot Function]

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