Mouse Akap9 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Akap9
Locus ID	100986
Kit Components	GA211628G1, Akap9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211628G2, Akap9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211628G3, Akap9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_194462
Synonyms	5730481H23Rik; AKAP-9; AKAP450; AW545847; C79026; G1-448-15; mei2-5; mKIAA0803; PRKA9; repro12
Summary	Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 2/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 2, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery.[UniProtKB/Swiss-Prot Function]

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