Mouse Rita1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rita1
Locus ID	100764
Kit Components	GA211621G1, Rita1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211621G2, Rita1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211621G3, Rita1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029096, NM_133908
Synonyms	1110008J03Rik; AI853657; C86297; Rita
Summary	Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity).[UniProtKB/Swiss-Prot Function]

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