Mouse Sh3bp4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sh3bp4
Locus ID	98402
Kit Components	GA211506G1, Sh3bp4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211506G2, Sh3bp4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211506G3, Sh3bp4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_133816
Synonyms	AI594717; AW227605; BOG25
Summary	May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).[UniProtKB/Swiss-Prot Function]

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