Mouse Sgsm2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sgsm2
Locus ID	97761
Kit Components	GA211482G1, Sgsm2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211482G2, Sgsm2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211482G3, Sgsm2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_197943
Synonyms	D630003G22Rik; mKIAA0397; R74628; Rutbc1
Summary	Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).[UniProtKB/Swiss-Prot Function]

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