Mouse Slc4a10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Slc4a10
Locus ID	94229
Kit Components	GA211439G1, Slc4a10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211439G2, Slc4a10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211439G3, Slc4a10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001242378, NM_001242379, NM_001242380, NM_001242381, NM_001242382, NM_001242383, NM_033552, NM_001362671, NM_001362672, NM_001362673, NM_001362674, NM_001362675, NM_001362676
Synonyms	mKIAA4136; NCBE
Summary	Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:10993873, PubMed:20566632). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (PubMed:18165320). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (PubMed:26136660). Required in retinal cells to maintain normal pH which is necessary for normal vision (PubMed:23056253). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).[UniProtKB/Swiss-Prot Function]

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