Mouse Ophn1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ophn1
Locus ID	94190
Kit Components	GA211422G1, Ophn1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211422G2, Ophn1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211422G3, Ophn1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001313754, NM_001313755, NM_001313756, NM_052976
Synonyms	C130037N19Rik; Wtgr
Summary	Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.[UniProtKB/Swiss-Prot Function]

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