Mouse Dnaja3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dnaja3
Locus ID	83945
Kit Components	GA211267G1, Dnaja3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211267G2, Dnaja3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211267G3, Dnaja3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135112, NM_023646
Synonyms	1200003J13Rik; 1810053A11Rik; C81173; Tid-1; Tid1l
Summary	Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.[UniProtKB/Swiss-Prot Function]

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