Mouse Otof activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Otof
Locus ID	83762
Kit Components	GA211255G1, Otof gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211255G2, Otof gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211255G3, Otof gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001100395, NM_001286421, NM_001313767, NM_031875
Synonyms	MGC183613
Summary	Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes.[UniProtKB/Swiss-Prot Function]

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