Mouse Rbm5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rbm5
Locus ID	83486
Kit Components	GA211229G1, Rbm5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211229G2, Rbm5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211229G3, Rbm5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_148930, NM_001359524, NM_001359525, NM_001359526, NR_153190, NR_153191
Synonyms	D030069N10Rik
Summary	Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity).[UniProtKB/Swiss-Prot Function]

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