Mouse Wrnip1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Wrnip1
Locus ID	78903
Kit Components	GA211064G1, Wrnip1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211064G2, Wrnip1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211064G3, Wrnip1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_030215
Synonyms	4833444L21Rik; WHIP; Wrnip
Summary	Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.[UniProtKB/Swiss-Prot Function]

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