Mouse Ints7 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ints7
Locus ID	77065
Kit Components	GA210703G1, Ints7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210703G2, Ints7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210703G3, Ints7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001306203, NM_001306204, NM_178632
Synonyms	5930412E23Rik; int7
Summary	Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.[UniProtKB/Swiss-Prot Function]

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