Mouse Trdn activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Trdn
Locus ID	76757
Kit Components	GA210598G1, Trdn gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210598G2, Trdn gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210598G3, Trdn gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029726, NM_001364696, NM_001364697
Synonyms	2310045H21Rik; EG432451; TDN
Summary	Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength (PubMed:19843516). Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.[UniProtKB/Swiss-Prot Function]

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