Mouse Ppp1r11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ppp1r11
Locus ID	76497
Kit Components	GA210527G1, Ppp1r11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210527G2, Ppp1r11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210527G3, Ppp1r11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029632
Synonyms	1500041B02Rik; AV117883; Hcgv; Tcte5; Tctex-5; Tctex5
Summary	Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (By similarity).[UniProtKB/Swiss-Prot Function]

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