Mouse Il31 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il31
Locus ID	76399
Kit Components	GA210494G1, Il31 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210494G2, Il31 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210494G3, Il31 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029594
Synonyms	1700013B14Rik
Summary	Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and serum amyloid A protein expression in macrophages (PubMed:25847241).[UniProtKB/Swiss-Prot Function]

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