Mouse Dcstamp activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dcstamp
Locus ID	75766
Kit Components	GA210340G1, Dcstamp gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210340G2, Dcstamp gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210340G3, Dcstamp gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001289506, NM_001289508, NM_001289512, NM_001289513, NM_029422
Synonyms	4833414I07Rik; DC-STAMP; FIND; mDC-STAMP; Tm7sf4
Summary	Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.[UniProtKB/Swiss-Prot Function]

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