Mouse Sgf29 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sgf29
Locus ID	75565
Kit Components	GA210264G1, Sgf29 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210264G2, Sgf29 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210264G3, Sgf29 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029339
Synonyms	1700023O11Rik; 9530025I05Rik; Ccdc101
Summary	Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival.[UniProtKB/Swiss-Prot Function]

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