Mouse Meiob activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Meiob
Locus ID	75178
Kit Components	GA210123G1, Meiob gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210123G2, Meiob gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210123G3, Meiob gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_029197
Synonyms	4930528F23Rik; MLZ-675
Summary	Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.[UniProtKB/Swiss-Prot Function]

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