Mouse Clec16a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Clec16a
Locus ID	74374
Kit Components	GA209855G1, Clec16a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209855G2, Clec16a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209855G3, Clec16a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001204229, NM_177562
Synonyms	4932416N17Rik; curt; mKIAA0350
Summary	Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health.[UniProtKB/Swiss-Prot Function]

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