Mouse Crtc2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Crtc2
Locus ID	74343
Kit Components	GA209841G1, Crtc2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209841G2, Crtc2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209841G3, Crtc2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028881, NR_151631, NM_001357152
Synonyms	4632407F12Rik; mTORC2; Torc2
Summary	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).[UniProtKB/Swiss-Prot Function]

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