Mouse Fblim1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Fblim1
Locus ID	74202
Kit Components	GA209782G1, Fblim1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209782G2, Fblim1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209782G3, Fblim1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163256, NM_133754
Synonyms	2410043F08Rik; Cal; Fblp1; Gt10; migfilin; migfilin(s)
Summary	Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity).[UniProtKB/Swiss-Prot Function]

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