Mouse Dtx2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dtx2
Locus ID	74198
Kit Components	GA209778G1, Dtx2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209778G2, Dtx2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209778G3, Dtx2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256096, NM_001256097, NM_001256098, NM_023742
Synonyms	2610524D08Rik; AA408415; AU022494; Deltex2
Summary	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).[UniProtKB/Swiss-Prot Function]

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