Mouse Zdhhc16 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Zdhhc16
Locus ID	74168
Kit Components	GA209759G1, Zdhhc16 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209759G2, Zdhhc16 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209759G3, Zdhhc16 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_023740, NM_001360676, NM_001360679
Synonyms	1500015N03Rik; Aph2
Summary	Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:26644582). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (PubMed:26644582). Also required for eye development (PubMed:26644582). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (PubMed:27159997). May be involved in apoptosis regulation (PubMed:12021275). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).[UniProtKB/Swiss-Prot Function]

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