Mouse Nuak2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nuak2
Locus ID	74137
Kit Components	GA209738G1, Nuak2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209738G2, Nuak2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209738G3, Nuak2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001195025, NM_028778
Synonyms	1200013B22Rik; mKIAA0537; Omphk2; Snark
Summary	Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).[UniProtKB/Swiss-Prot Function]

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