Mouse Rnf6 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rnf6
Locus ID	74132
Kit Components	GA209735G1, Rnf6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209735G2, Rnf6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209735G3, Rnf6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256085, NM_001256086, NM_001256087, NM_028774
Synonyms	1200013I08Rik; 5730419H05Rik; AA537053
Summary	E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.[UniProtKB/Swiss-Prot Function]

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