Mouse Msl1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Msl1
Locus ID	74026
Kit Components	GA209681G1, Msl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209681G2, Msl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209681G3, Msl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028722, NM_001361931, NM_001361932, NM_001361933, NM_001361934
Synonyms	2810017F12Rik; 4121402D02Rik; 4930463F05Rik; AA682082; Msl-1
Summary	Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-17' which is implicated in the formation of higher-order chromatin. structure (By similarity). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.[UniProtKB/Swiss-Prot Function]

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