Mouse Mfsd12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mfsd12
Locus ID	73822
Kit Components	GA209617G1, Mfsd12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209617G2, Mfsd12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209617G3, Mfsd12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028657
Synonyms	C19orf28; F630110N24Rik; Wdt1
Summary	Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin/hair pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin/hair pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells (By similarity).[UniProtKB/Swiss-Prot Function]

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