Mouse Thap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Thap1
Locus ID	73754
Kit Components	GA209602G1, Thap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209602G2, Thap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209602G3, Thap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_199042
Synonyms	4833431A01Rik; AW490810
Summary	DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).[UniProtKB/Swiss-Prot Function]

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