Mouse Rec114 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rec114
Locus ID	73673
Kit Components	GA209574G1, Rec114 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209574G2, Rec114 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209574G3, Rec114 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_028598
Synonyms	2410076I21Rik; 4930527A11Rik
Summary	Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).[UniProtKB/Swiss-Prot Function]

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