Mouse Insig2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Insig2
Locus ID	72999
Kit Components	GA209385G1, Insig2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209385G2, Insig2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209385G3, Insig2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001271531, NM_001271532, NM_133748, NM_178082, NM_001357251
Synonyms	2900053I11Rik; C730043J18Rik; Insig-2
Summary	Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.[UniProtKB/Swiss-Prot Function]

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