Mouse Marchf1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Marchf1
Locus ID	72925
Kit Components	GA209365G1, Marchf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209365G2, Marchf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209365G3, Marchf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001166372, NM_001166375, NM_001293784, NM_175188, NM_001363123, NM_001363124, NM_001363125
Synonyms	2900024D24Rik; BB085186
Summary	E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.[UniProtKB/Swiss-Prot Function]

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